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AbstractIn men with impaired semen parameters, empiric medical therapies such as clomiphene citrate, a selective estrogen receptor modulator (SERM), and anastrozole, a selective aromatase inhibitor, are often employed. The effects of jointly administering these agents on semen parameters are not we...
IntroductionMany couples struggle with infertility worldwide; however, the etiology of abnormal semen analysis (SA) parameters is not identified in up to 45% of men (1,2). These individuals are often initiated on empiric medical therapy consisting of either aromatase inhibitors to block the periphe...
MethodsStudy population and biospecimen collectionWe performed a multi-center, retrospective cohort study of men with idiopathic infertility who were prescribed anastrozole at two tertiary referral centers: University of California, Los Angeles, and Cleveland Clinic. Semen parameters, in addition t...
ResultsNinety participants were included in this analysis; baseline characteristics of all participants are reported in our recently published study (4). In brief, the median age of participants was 36 (IQR, 32–41) years, body mass index (BMI) 32 (IQR, 27–43) kg/m2, and anastrozole dose 3 (IQR,...
DiscussionManagement of idiopathic, male factor infertility with empiric medical therapy remains a challenge as there are limited data to guide clinicians. In this brief report, we explore the effect of clomiphene and anastrozole combination therapy compared to anastrozole monotherapy on semen para...
ConclusionsIn men with idiopathic infertility, addition of clomiphene to anastrozole provides modest improvement to semen parameters. Although there were no significant differences between WHO semen classification upstaging, men on combination therapy showed a significant improvement in TMSC, which...
SupplementaryThe article’s supplementary files as...
AcknowledgmentsWe would like to acknowledge the assistance of Neilufar Modiri from Division of Andrology, Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, United States of America in assisting with data collection for this project. Funding: None. Ethical...
FootnotesConflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tau. amegroups. com/article/view/10...
References1. Punab M, Poolamets O, Paju P, et al. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts...
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